Translate

CORONAVIRUS COVID-19 Global Cases by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU) ...

domingo, 27 de enero de 2019

Veneno de escorpión para ayudar a transportar fármacos a través de la barrera hematoencefálica

From venoms to BBB-shuttles. MiniCTX3: a molecular vector derived from scorpion venom

Abstract

The present study aims to develop chlorotoxin (CTX), from Giant Yellow Israeli scorpion venom, as a new BBB-shuttle. Minimised versions of CTX were prepared to reduce its complexity while enhancing its BBB-shuttle capacity and preserving its protease-resistance. MiniCTX3, a monocyclic lactam-bridge peptidomimetic, was capable of transporting nanoparticles across endothelial cell monolayers. Our results reveal animal venoms as an outstanding source of new families of BBB-shuttles.
Graphical abstract: From venoms to BBB-shuttles. MiniCTX3: a molecular vector derived from scorpion venom

No hay comentarios:

Publicar un comentario

Aportes