La indagación científica en la línea Neurociencia-Cognición-Aprendizaje, facilita encontrar relaciones entre factores que afectan la triada salud humana, aprendizaje y desempeño. A su vez, Aprendizaje y Felicidad, son know-how tan íntimamente ligados que al resultar alterados forman barreras que convergen en frustración de las personas, requiriendo un diagnóstico/manejo oportuno/apropiado para superarlas. Es el eje de trabajo al revisar artículos de la investigación científica en este blog.
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CORONAVIRUS COVID-19 Global Cases by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU) ...
domingo, 21 de abril de 2019
Un material biocompatible ayuda a células madre a recuperar un área dañada por isquemia cerebral
Stem cell transplantation is a promising strategy to treat brain injuries. However, cell-based therapies are limited because poor local cell engraftment. Here, we present a polylactic acid (PLA) scaffold to support mesenchymal stem cells (MSCs) delivery in stroke. We isolated bone marrow MSCs from adult C57/Bl6 mice, cultured them on PLA polymeric rough microfibrous (PRM) scaffolds obtained by rotary jet spinning, and transplanted over the brains of adult C57/Bl6 mice, carrying thermocoagulation-induced cortical stroke. No inflammatory response to PRM was found. MSCs transplantation significantly reduced the area of the lesion and PRM delivery increased MSCs retention at the injury site. In addition, PRM upregulated α6-integrin and CXCL12 production, which may be the cause for greater cell retention at the lesion site and may provide additional benefit to MSCs transplantation procedures. We conclude that PRM scaffolds offer a promising new system to deliver stem cells to injured areas of the brain.
Graphical abstract
Synthetic scaffolds offer an alternative to optimize stem cell transplantation at sites of brain injury. Here, we present a rotary jet spun polylactic acid (PLA) polymer used as a scaffold to support delivery of mesenchymal stem cells (MSCs) in a mouse model of stroke. Transplantation of MSCs isolated or cultured on PRM significantly reduced the area of the lesion and PRM delivery increased MSCs retention at the injury site.
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